Efectividad del uso transoperatorio de solución electrolizada de superoxidación para la prevención de infecciones postoperatorias en cirugía de terceros molares / Effectiveness of the trans-operative use of electrolyzed superoxidation solution for the prevention of post-operative infections in third molar surgery

La cirugía de terceros molares es uno de los procedimientos más realizados dentro de la práctica odontológica, generalmente conlleva la prescripción de fármacos, incluidos antibióticos indicados para prevenir la aparición de procesos infecciosos. La resistencia antimicrobiana es considerada como un problema de salud pública a nivel mundial, por lo que el uso de antibióticos debe ser cauteloso. La solución electrolizada de súperoxidación ha demostrado tener efectos bactericidas, virucidas y ha sido utilizada para la prevención y el tratamiento de procesos infecciosos. El objetivo del presente estudio fue demostrar la efectividad de dicha solución en la prevención de infecciones posteriores a la cirugía de terceros molares. Se realizó un estudio aleatorizado, ciego, prospectivo en 20 pacientes utilizando un diseño split mouth, en donde cada paciente fue sujeto control y experimental, en el grupo control se irrigó durante el procedimiento con solución de súperoxidación y no se prescribió antibiótico posterior, mientras que en el grupo control se irrigó con solución fisiológica y se prescribió antibiótico posterior. Se realizaron 40 cirugías en 20 pacientes utilizando en cada paciente ambas terapéuticas. Se analizó el dolor postoperatorio, inflamación y presencia de infección. El dolor y la inflamación fueron ligeramente superiores en el grupo experimental al tercer día; sin embargo, al séptimo día los resultados fueron similares. No se presentó ningún caso de infección postoperatoria. El uso de solución de súperoxidación transoperatoria puede ser una herramienta muy útil en la prevención de infecciones postoperatorias posterior a cirugía de terceros molares en pacientes sanos en cirugías con dificultad leve a moderada (AU)

Third molar surgery is one of the most performed procedures in dental practice, generally involving the prescription of drugs including antibiotics indicated to prevent the onset of infectious processes. Antimicrobial resistance is considered a public health problem worldwide, so the use of antibiotics should be cautious. The electrolyzed super oxidation solution has been shown to have bactericidal and virucidal effects and has been used for the prevention and treatment of infectious processes. The objective of the present study was to demonstrate the effectiveness of said solution in the prevention of infections after third molar surgery. A randomized, blind, prospective study was conducted in 20 patients using a split mouth design where each patient was a control and experimental subject, in the control group they were irrigated during the procedure with super oxidation solution and no subsequent antibiotic was prescribed. while the control group was irrigated with physiological solution and a subsequent antibiotic was prescribed. Forty surgeries were performed on 20 patients using both therapies in each patient. Postoperative pain, inflammation and presence of infection were analyzed. Pain and inflammation were slightly higher in the experimental group on third day, however on seventh day the results were similar. There were no cases of postoperative infection. The use of trans operative super oxidation solution can be a very useful tool in the prevention of postoperative infections after third molar surgery in healthy patients undergoing surgeries with mild to moderate difficulty.(AU)

Preemptive use of intravenous ibuprofen to reduce postoperative pain after lower third molar surgery: a systematic review of randomized controlled trials

This study aimed to systematically review the literature to assess the effect of preemptive intravenous ibuprofen on pain reduction after lower third molar surgery. Nine databases (PubMed, Scopus, LILACS, SciELO, Embase, Web of Science, Cochrane, Open Gray, and Open Thesis) were used as sources of research, including "grey literature." The protocol was registered in PROSPERO. Only randomized clinical trials evaluating the effects of preemptive intravenous ibuprofen on pain during and immediately after the extraction of lower third molars were included, without restrictions of year and language. Two reviewers independently performed the study selection, data extraction, and assessment of the risk of bias. The "Joanna Briggs Institute for Randomized Controlled Trials" tool was used to assess the risk of bias. Each study was categorized according to the percentage of positive responses to the questions corresponding to the assessment instrument. The results were measured narratively/descriptively. The initial search resulted in 3,257 records, of which only three studies (n=150 participants) met the eligibility criteria and were included in the qualitative analysis. All studies were published in 2019. The risk of bias ranged from low to moderate. Two studies found significant pain reduction within 48 h after the procedure. In conclusion, the use of preemptive intravenous ibuprofen for extracting third molars reduces pain and analgesic consumption after the surgical procedure.

Terapia antibiótica postoperatoria en pacientes sanos sometidos a cirugía de terceros molares impactados / Postoperative antibiotic therapy in healthy patients who underwent impacted third molar surgery

RESUMEN: Introducción: La adición de tratamiento antibiótico al tratamiento analgésico en el manejo postoperatorio de cirugía de terceros molares en pacientes sanos, ha sido propuesta principalmente para prevenir complicaciones postoperatorias. Sin embargo, es una terapia controvertida en la actualidad. Métodos: Realizamos una búsqueda en Epistemonikos, la mayor base de datos de revisiones sistemáticas en salud, la cual es mantenida mediante el cribado de múltiples fuentes de información, incluyendo MEDLINE, EMBASE, Cochrane, entre otras. Extrajimos los datos desde las revisiones identificadas, analizamos los datos de los estudios primarios, realizamos un metaanálisis y preparamos una tabla de resumen de los resultados utilizando el método GRADE. Resultados y conclusiones: Identificamos siete revisiones sistemáticas que en conjunto incluyeron ocho estudios primarios, de los cuales siete corresponden a ensayos aleatorizados. Concluimos que la adición del tratamiento antibiótico postoperatorio en cirugía de terceros molares en pacientes sanos, disminuye la incidencia de fiebre y probablemente disminuye el desarrollo de infección. Además, podría disminuir la inflamación, pero la certeza de la evidencia es baja. Finalmente, no existe claridad de que la adición de un tratamiento antibiótico postoperatorio en cirugía de terceros molares disminuya el dolor y otros efectos adversos ya que la certeza de la evidencia ha sido evaluada como muy baja.

ABSTRACT: Introduction: Postoperative antibiotic therapy in addition to analgesics for impacted third molar surgery in healthy patients has been proposed to prevent postoperative complications. However, antibiotic use in healthy patients is still controversial. Methods: We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. Results and conclusions: We identified seven systematic reviews including eight studies overall, of which seven were randomized trials. We conclude that postoperative antibiotic therapy compared with no antibiotic treatment in healthy patients who underwent third molar surgery reduces the risk of fever and probably reduces the risk of infection. Also, it may reduce inflammation, but the certainty of the evidence has been assessed as low. Finally, we are uncertain whether the addition of a postoperative antibiotic in third molar surgery reduces pain and other adverse events, as the certainty of the evidence has been assessed as very low.

The Efficacy of Two Different Concentrations of Local Anaesthetic on Pain in Mandibular Third Molar Surgery

@#Mepivacaine is a common local anaesthetic used with claims of a high safety profile. There are two commercial types, 2% mepivacaine with vasoconstrictor and 3% without vasoconstrictor. There are many suggestions regarding the usage of plain 3% without vasoconstrictor for systemic medical problems, however, there have not been any previous studies to confirm this necessity in impacted lower third molar surgery (ILTMS). This study aims to evaluate the anaesthetic efficiency and the effect on the patient of 2% and 3% mepivacaine, adding vasoconstrictor to the 3% mepivacaine. This crossover study comprised of 24 patients with bilateral, symmetrically positioned, impacted lower third molars. Patients received either 2% or 3% mepivacaine for the inferior alveolar nerve block (IANB). Onset and duration of anaesthesia, and haemodynamic considerations were analysed as primary outcomes. Furthermore, pain, duration of postoperative anaesthesia and pulp vitality were analysed as secondary outcomes. Different concentrations of mepivacaine showed similar anaesthetic onset time (p > 0.05). There was no statistically significant difference regarding the duration of anaesthesia, as well as the postoperative analgesia (p > 0.05). The two concentrations did not lead to any haemodynamic changes or complications during ILTMS. Thus, adding the vasoconstrictor to mepivacaine 3% did not cause any adverse effects on the patients intra or postoperatively. Therefore, it is possible for dentists to use only 2% mepivacaine with vasoconstrictor for IANB effectively and safely when the case necessitates the need for a vasoconstrictor, or in other words, longer duration of haemostasis.

A Comparative Study of the Effect of Primary and Secondary Closure Technique Following Removal of Impacted Mandibular Third Molars

Introduction: Surgical removal of the impacted mandibularthird molar is one of the most frequently performed surgicalprocedures in oral and maxillofacial surgery. The purpose ofthis study was to compare the primary and secondary woundclosure after surgical removal of impacted mandibular thirdmolars by evaluating the extent of facial swelling, the severityof pain and degree of trismus.Material and Methods: A prospective, randomized,clinical trial was conducted in 80 patients. The patients wererandomly divided into two groups of 40 each. In Group 1:patients underwent primary closure of the wound and inGroup 2: patients underwent secondary closure of the wound.Postoperative pain, swelling, and trismus were evaluated onthe 2nd and 7th day postoperatively.Results: Statistically significant difference was observed forfacial swelling and trismus on 2nd postoperative days betweenboth groups. Postoperative pain was less in the secondaryclosure group.Conclusion: From the outcome of the above study we canconclude that the secondary wound closure technique has asignificant advantage over primary wound closure concerningswelling and trismus.

Parálisis del XI par craneal secundaria a enfisema subcutáneo por uso de pieza de mano de alta velocidad en cirugía de terceros molares / Paralysis of the XI cranial nerve following subcutaneous emphysema by use of high speed handpiece in third molar surgery

Introducción: La cirugía de los terceros molares es el procedimiento quirúrgico más frecuentemente realizado por los cirujanos orales y maxilofaciales, que a pesar de contar con una vasta experiencia y entrenamiento en el área quirúrgica pueden presentarse complicaciones transoperatorias y postoperatorias. Cuando éste es realizado por un cirujano dentista de práctica general las complicaciones pueden aumentar. Presentación de caso clínico: Se trata de un paciente de 25 años de edad sometido a extracción quirúrgica de terceros molares por un dentista de práctica general, el cual realiza procedimiento quirúrgico con uso de pieza de mano de alta velocidad. Tres días posteriores al evento quirúrgico el paciente acude al Departamento de Cirugía Oral y Maxilofacial del Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado por presentar edema, infl amación y crepitación en región bucal, maseterina y submandibular derecha, así como limitación a la apertura bucal de 25 mm. En tomografía computarizada contrastada se obs erva desviación de la vía aérea hacia el lado izquierdo. Se decide manejó del proceso infeccioso y de enfi sema subcutáneo con farmacoterapia y drenaje del mismo. Una vez remitido el enfi sema subcutáneo, en la cuarta semana de evolución el paciente refi ere limitación a la abducción del hombro derecho, observándose atrofi a del músculo trapecio y esternocleidomastoideo ipsilateral, correspondiente a lesión del XI par craneal. Discusión: La lesión del nervio accesorio (XI par craneal) ocasiona parálisis del músculo trapecio, principal estabilizador de la escápula que contribuye en los movimientos de fl exión, rotación y abducción del hombro. El trayecto del XI par craneal es superfi cial en el triángulo posterior del cuello presentando susceptibilidad a ser lesionado de manera iatrogénica, en este caso la utilización de pieza de mano de alta velocidad durante la extracción quirúrgica de los terceros molares generó enfi sema subcutáneo que condicionó la posible compresión del nervio accesorio, lesionando al mismo (AU)

Introduction: The third molar surgery is the most frequent surgical procedure performed by oral and maxillofacial surgeons, who despite their vast experience and training in the surgical area can present transoperatory and postoperative complications. When the oral surgery is done by a general practice dentist the complications can be increased. Case presentation: A 25-year-old male patient undergoing third molar surgery by a general practice dentist who performs a surgical procedure using a high-speed handpiece. Three days after the surgical procedure patient comes to the Department of Oral and Maxillofacial Surgery Institute for Social Security and Services for State Workers by present edema, swelling and crepitus in buccal space, masseteric and right submandibular region and limitation of mouth opening of 25 mm. Contrast computed tomography shows airway deviation to the left side. We decided to manage the infectious process and subcutaneous emphysema with antibiotic therapy and drainage. After subcutaneous emphysema was in remission, in the fourth week of evolution, the patient reported limitation of abduction of the right shoulder, with atrophy of the trapezius muscle and ipsilateral sternocleidomastoid, corresponding to a lesion of the XI cranial nerve. Discussion: Accessory nerve injury (XI cranial nerve) causes palsy of the trapezius muscle, the major stabilizer of the scapula that contributes to the fl exion, rotation and abduction movements of the shoulder. The trajectory of the XI cranial nerve is superfi cial in the posterior triangle of the neck presenting susceptibility to iatrogenic injury, in this case, the use of high-speed handpiece during the surgical extraction of the third molars, caused subcutaneous emphysema that conditioned the possible compression of the spinal nerve (AU)

Efficacy of ketoprofen with or without omeprazole for pain and inflammation control after third molar removal

Abstract In view of the gastrointestinal problems generated by the ketoprofen use, the ketoprofen association with omeprazole is available on the market. However, this association efficacy in acute pain control has not been established. Bilateral extraction of lower third molars in similar positions is currently the most used model for the evaluation and investigation of the efficacy and pharmacological effects of new compounds for the treatment of acute postoperative pain. The randomized and crossover study consisted in evaluating the clinical efficacy of therapy performed by ketoprofen 100 mg (twice daily-b.i.d.) versus ketoprofen 200 mg + omeprazole 20 mg (once daily-q.d.) to pain, swelling and trismus control in the bilateral extraction model of lower third molars in similar positions in two different appointments, in 50 volunteers. Volunteers reported significantly less postoperative pain at various post-operative periods and consumed less rescue analgesic medication (acetaminophen 750 mg) throughout the study when they took the combination of ketoprofen 200 mg + omeprazole 20 mg (q.d.). Following administration of both study drugs, no gastrointestinal adverse reactions were reported by volunteers. Furthermore, the evaluations of the drugs in pain control by the volunteers were significantly favorable to ketoprofen 200 mg + omeprazole 20 mg (q.d.). For swelling and trismus control, the treatments presented similar results. In conclusion, when volunteers took ketoprofen 200 mg + omeprazole 20 mg (q.d.), they reported significantly less postoperative pain at various post-surgical periods and consumed less rescue analgesic medication throughout the study compared with ketoprofen 100 mg (b.i.d).

Resumo Em vista dos problemas gastrointestinais gerados pelo uso do cetoprofeno, a associação do cetoprofeno com o omeprazol está disponível no mercado. No entanto, esta eficácia de associação no controle da dor aguda não foi estabelecida. A extração bilateral de terceiros molares inferiores em posições semelhantes é atualmente o modelo mais utilizado para a avaliação e investigação da eficácia e efeitos farmacológicos de novos compostos para o tratamento da dor aguda pós-operatória. O estudo randomizado e cruzado consistiu na avaliação da eficácia clínica da terapia com cetoprofeno 100 mg (duas vezes ao dia-b.i.d.) versus cetoprofeno 200 mg + omeprazol 20 mg (uma vez ao dia-q.d.) para o controle da dor, do edema e do trismo no modelo bilateral de terceiros molares inferiores em posições semelhantes em duas consultas diferentes, em 50 voluntários. Os voluntários relataram significativamente menos dor pós-operatória em vários períodos pós-operatórios e consumiram menos medicação analgésica de socorro (acetaminofeno 750 mg) durante todo o estudo quando tomaram a combinação de 200 mg de cetoprofeno + 20 mg de omeprazol (q.d.). Após a administração de ambas as drogas do estudo, nenhuma reação adversa gastrointestinal foi relatada pelos voluntários. Além disso, as avaliações das drogas no controle da dor pelos voluntários foram significativamente favoráveis ​​ao cetoprofeno 200 mg + omeprazol 20 mg (q.d.). Para o controle do edema e do trismo, os tratamentos apresentaram resultados semelhantes. Em conclusão, quando os voluntários tomaram 200 mg de cetoprofeno + 20 mg de omeprazol (q.d.), eles relataram significativamente menos dor pós-operatória em vários períodos pós-cirúrgicos e consumiram menos medicação analgésica de socorro durante o estudo comparado com 100 mg de cetoprofeno (b.i.d).

Inferior alveolar nerve block by intraosseous injection with Quicksleeper® at the retromolar area in mandibular third molar surgery

BACKGROUND: There are many techniques of inferior alveolar nerve block injection (IANBI); one among them is the computer-assisted intraosseous injection (CAIOI). Here we aim to evaluate the effectiveness of CAIOI with Quicksleeper® in mandibular third molar surgery. METHODS: This study is a clinical, single-blind, randomized, split-mouth, controlled trial including 25 patients (10 males and 15 females, mean age 21 years). The patients underwent surgical removal of bilateral mandibular third molars with two different IANBI techniques. One side was injected using Quicksleeper®, and the other side was injected using a conventional IANBI. Both techniques used one cartridge (1.7 ml) of 1:100,000 epinephrine 4% articaine. A supplementary injection was used if necessary. All volumes of anesthetic agent used were recorded. Statistical analysis was performed using paired t-test and Wilcoxon test. RESULTS: This research showed that CAIOI has faster onset and shorter duration of action than IANBI (P < 0.05). The pain was similar in both techniques. In the CAIOI group, one-third of the cases could be completed without additional anesthesia. The remaining two-thirds required minimal supplementary volume of anesthesia. The success rates were 68% for CAIOI and 72% for IANBI, respectively. CONCLUSION: CAIOI is an advantageous anesthetic technique. It can be used as an alternative to conventional IANBI for mandibular third molar surgery.

Comparative Clinical Evaluation of Submucosal and Intramuscular Dexamethasone In Reducing Post Operative Sequelae Following Impacted Mandibular Third Molar Surgery.

Background and Objectives: To understand the benefi ts of dexamethasone and to compare the effect of submucosal versus intramuscular administration of dexamethasone in reducing post operative sequelae following impacted mandibular third molar surgery. Materials and Methods: The study was conducted on 90 patients, who were divided into three groups of 30 each. The two experimental groups were given dexamethasone 4 mg submucosally or intramuscularly(preoperatively), and the control group did not receive any form of corticosteroid. Measurement of facial swelling, maximal interincisal distance were made pre operatively and on the fi rst, third and seventh post operative day. Pain was evaluated from patients response to visual analogue scale (VAS) and recording the number of rescue analgesic tablets taken at the end of seventh postoperative day. Results: Both dexamethasone groups showed a signifi cant reduction in pain, swelling and trismus as compared with the control group at all intervals. There was a statistically signifi cant reduction in magnitude of swelling in submucosal dexamethasone group as compared to intramuscular dexamethasone group on the 1st post operative day, but there was no signifi cant difference among two experimental groups at other times and their effects were comparable for all variables. Conclusion: Dexamethasone 4 mg is an effective therapeutic strategy for reducing post operative sequelae following surgical removal of impacted third molars and submucosal dexamethasone is an effective alternative to dexamethasone given systemically.

Comparison of Analgesic Efficacy of Tramadol and Tapentadol in Impacted Mandibular Third Molar Surgery: A Randomized, Double Blind Clinical Study.

Introduction: The chronological age of eruption of third molars is between 18 and 24 years with wide variation in the eruption time. The eruption failure being very common makes the extraction of impacted third molars one of the most frequent surgical procedures in the maxillofacial region. Materials and Methods: A study was conducted on one hundred patients who visited the Department of Oral and Maxillofacial Surgery, Subbiah institute of Dental Sciences for the removal of impacted mandibular third molars to compare the analgesic efficacy of tramadol and tapentadol in patients undergoing surgical extraction of impacted mandibular molars. Patients were divided into two equal groups, group A and group B. Patients were randomly assigned in either treatment groups with an assigned code. Both patient and investigator were not aware of the drug code. Group A patients received 50mg tramadol and group B patients received 50mg tapentadol orally immediately after surgery and 12 hours after surgery. Results: VAS score of group A was 6.22±0.65 and group B was 5.92±0.97 at the end of 2 hours. VAS score of group A was 6.18±1.08 and group B was 5.76±1.25 at the end of 8 hours. VAS score of group A was 6.36±0.96 and group B was 6.46±1.2 at the end of 12 hours. VAS score of group A was 6.2±1.2 and group B was 6.2±1.47 at the end of 24 hours. VAS scores, statistically were found to be in significant between two groups. All patients had moderate pain at the end of 2 hours, 92% of group A and 96% of group B patients had moderate pain at the end of 8 hours. Mild pain was noted in most patients around 24 hours according to the categorical pain scale. Conclusion: A study was conducted to compare the analgesic efficacy of tramadol and tapentadol on patients undergoing third molar surgeries. The results of the statistical analysis suggested that Tramadol and Tapentadol are effective in managing postoperative pain and neither of the drugs mentioned above were superior to other.

The efficacy of dexamethasone injection on postoperative pain in lower third molar surgery

BACKGROUND: Surgery on the lower impacted third molar usually involves trauma in the highly vascularized loose connective tissue area, leading to inflammatory sequelae including postoperative pain, swelling, and general oral dysfunction during the immediate post-operative phase. This study aimed to investigate the effectiveness of preoperative injection of a single dose of 8 mg dexamethasone for postoperative pain control in lower third molar surgery. METHODS: A controlled, randomized, split-mouth, prospective study involving lower third molar surgery was performed in 31 patients. The randomized sampling group was preoperatively injected, after local anesthesia, with a single dose of dexamethasone (8 mg in 2 ml) through the pterygomandibular space; 2 ml of normal saline (with no dexamethasone) was injected as a placebo. RESULTS: The pain VAS score was significantly different on the day of the operation compared to the first post-operative day (P = 0.00 and 0.01, respectively), but it was not significantly different on the third and seventh postoperative day between the control and study groups. There was a significant reduction in swelling on the second postoperative day, and a difference between the second postoperative day and baseline value in the study group (P < 0.05). Trismus was highly significantly different on the second postoperative day and between baseline and second postoperative day between the groups (P = 0.04 and 0.02, respectively). Descriptive statistics and independent-samples t- test were used to assess the significance of differences. CONCLUSIONS: Injection of 8 mg dexamethasone into the pterygomandibular space effectively reduced the postoperative pain and other postoperative sequalae.

The efficacy of dexamethasone injection on postoperative pain in lower third molar surgery

BACKGROUND: Surgery on the lower impacted third molar usually involves trauma in the highly vascularized loose connective tissue area, leading to inflammatory sequelae including postoperative pain, swelling, and general oral dysfunction during the immediate post-operative phase. This study aimed to investigate the effectiveness of preoperative injection of a single dose of 8 mg dexamethasone for postoperative pain control in lower third molar surgery. METHODS: A controlled, randomized, split-mouth, prospective study involving lower third molar surgery was performed in 31 patients. The randomized sampling group was preoperatively injected, after local anesthesia, with a single dose of dexamethasone (8 mg in 2 ml) through the pterygomandibular space; 2 ml of normal saline (with no dexamethasone) was injected as a placebo. RESULTS: The pain VAS score was significantly different on the day of the operation compared to the first post-operative day (P = 0.00 and 0.01, respectively), but it was not significantly different on the third and seventh postoperative day between the control and study groups. There was a significant reduction in swelling on the second postoperative day, and a difference between the second postoperative day and baseline value in the study group (P < 0.05). Trismus was highly significantly different on the second postoperative day and between baseline and second postoperative day between the groups (P = 0.04 and 0.02, respectively). Descriptive statistics and independent-samples t- test were used to assess the significance of differences. CONCLUSIONS: Injection of 8 mg dexamethasone into the pterygomandibular space effectively reduced the postoperative pain and other postoperative sequalae.

Complicaciones postoperatorias asociadas a la cirugía del tercer molar inferior retenido / Postoperative complications associated with impacted lower third molar surgery

Antecedentes: La cirugía del tercer molar inferior retenido es unprocedimiento de rutina en la práctica de la cirugía bucal. Varias complicaciones surgen como resultado de esta intervención quirúrgica. Entre las más frecuentes se encuentran: dolor, infl amación, trismo, hemorragia, equimosis, alveolitis, infección, parestesia y dificultad para comer. Objetivos: El propósito de este estudio fue evaluar la incidencia de complicaciones postoperatorias en la cirugía del tercer molar inferior retenido en pacientes de la Unidad Académica deOdontología de la Universidad Autónoma de Nayarit a fin de tenerlas en cuenta y tomar las respectivas precauciones, ya sea para tratar de evitarlas en lo sucesivo o bien, para reconocerlas y darles tratamiento. No se incluye dolor, infl amación ni trismo. Material y métodos: Este estudio fue longitudinal y prospectivo de siete días consecutivos y de 30 días en total en 38 pacientes entre 16 y 38 años de edad. Se evaluaron las complicaciones postoperatorias relacionadas con la cirugía del tercer molar inferior. Resultados: Participaron 38 pacientes; 29 del género femenino (76.3 por ciento) y 9 del masculino (23.7 por ciento) de entre 16 y 38 años, con un promedio de edad de 23.16 ± 5.2 años. La complicación más frecuente fue la difi cultad para masticar seguida de equimosis...

Background: Impacted lower third molar surgery is a routine pro-cedure in the practice of oral surgery. However, there are various complications associated with the extraction of impacted mandibular third molars, the most common being pain, swelling, trismus, hemor-rhaging, ecchymosis, dry socket, infection, paresthesia, and diffi culty with chewing. Objectives: The aim of this study was to evaluate the incidence of postoperative complications following impacted lower third molar surgery in patients at the Academic Unit of Dentistry of the Autonomous University of Nayarit, so as to ensure these are taken into account and that the respective precautions are taken, either by attempting to avoid them in the future or to recognize and treat them. Pain, infl ammation and trismus are not analyzed in this paper. Material and methods: A longitudinal prospective study of 38 patients between the ages of 16 and 38 years old (with an average age 23.1) was carried out over seven consecutive days, with follow up examination performed at 15 and 30 days. The postoperative complications associated with lower third molar surgery were assessed. Results: 38 patients took part; 29 females (76.3%) and 9 males (23.7%) between the ages of 16 and 38 years, with a mean age of 23.16 ± 5.2 years old. The most common complication was diffi culty with chewing followed by ecchymosis...

Relación de los niveles plasmáticos de proteína C reactiva con infección y edema en la cirugía de los terceros molares retenidos / Relation between CRP levels as indicator of postoperative infection and edema after third molar impacted surgery

La proteína C reactiva CRP (por sus siglas en inglés) es una proteína de fase aguda que se utiliza para el seguimiento de enfermedades inflamatorias tales como artritis reumatoidea, lupus eritematoso o vasculitis y procesos infecciosos tales como sepsis y septicemia; así como también, para evaluar la eficacia de las drogas antiinflamatorias y antimicrobianas indicadas en el tratamiento de estas patologías. Igualmente se ha asociado a daño tisular en diversas especialidades quirúrgicas. El objetivo de este estudio fue relacionar los niveles plasmáticos de CRP con la infección y el edema posterior a la cirugía de los terceros molares. A tal efecto se evaluaron 60 pacientes, distribuidos en 3 grupos A, B y C bajo antibioticoterapia profiláctica con Clindamicina (A: dosis única de 600 mg, B: 300 mg c/6h por 5 días y C: Placebo) y terapia analgésica y antiinflamatoria (Ibuprofeno 400mg c/6h por 3 días). A quienes se tomaron muestras de sangre antes y a las 72 horas de la odontectomía de los terceros molares y fotografías digitales para calcular el área de inflamación. No se demostró la relación de los niveles de CRP con infección ya que ningún paciente presentó proceso infeccioso pero si se demostró la relación cualitativa (sensibilidad) de CRP y cuantitativa mediante correlación de Spearman (p<0,05) ya que mientras mayor fue el área de la inflamación, mayores fueron los niveles plasmáticos de CRP.

The C reactive protein (CRP) is an unspecific acute phase reaction used for the follow-up of such inflammatory diseases such as rheumatoid arthritis, lupus, or vasculitis and such infectious processes like sepsis; as well as also, to evaluate the efficiency of the anti-inflammatory and antimicrobial drugs indicated in the treatment of this pathologies. Equally it has associated to tissue damage in diverse surgical specialties. The aim of this study was to evaluate the relation between CRP levels as indicator of postoperative infection and edema after third molar surgery. We evaluated 60 patients distributed in three groups A, B and C under antibiotic prophylaxis with Clindamycin (A: single dosis 600 mgs, B: 300 mgs each 6/h by 5 days and C: placebo) and analgesic and anti-inflammatory therapy with Ibuprofen 400 mg. each 6/h by 3 days. Who were taken blood samples to measure the CRP before and 72 hours after surgery and digital photographs to calculate the edema area. We did not demonstrated relation between CRP and infection because no one patient was infected in any group but we demonstrated (By Searman (p<0,05) the value of CRP as indicator of edema in the third molar surgery.

Uso de corticosteroide no pré-operatório em cirurgia de terceiros molares / Uso de corticosteroide no pré-operatório em cirurgia de terceiros molare

A remoção de terceiros molares é um procedimento cirúrgico comum realizado por cirurgiões-dentistas. Trismo, dor e edema são reflexos da inflamação, decorrente do traumatismo cirúrgico, e o corticosteroide tem sido utilizado com eficácia para a redução destas complicações. Este fármaco modula os eventos inflamatórios pela inibição da fosfolipase A2, provocando uma melhora em diversas manifestações clinicas. Em Odontologia, metilprednisolona, betametasona e dexametasona vêm sendo abordadas em estudos, para os quais variam dosagens e vias de administração. Em longo prazo, esta classe de medicamentos pode causar efeitos colaterais. Porém, uma dose pré cirurgicamente não causa efeitos adversos severos. Este estudo tem como objetivo oferecer informações sobre o uso de corticosteroide no pré-operatório em cirurgia de terceiro molar.

The removal of third molars is a common surgical procedure performed by dentists. Trismus, pain and swelling are reflective of inflammation due to surgical trauma and corticosteroids have been used effectively to reduce these complications. The drug modulates the inflammatory events by inhibiting phospoliphase A2, leading to an improvement in various clinical manifestations. In dentistry, methylprednisolone, betamethasone and dexamethasone have been addressed in studies which vary dosages and routs of administration. However, in the long run, this class of drugs can cause side effects. However, a dose before surgery does not cause severe adverse effects. This study aims to provide information about the use of steroids preoperatively in third molar surgery.

Relación de los niveles plasmáticos de proteína C reactiva con infección y edema en la cirugía de los terceros molares retenidos / Relation between CRP levels as indicator of postoperative infection and edema after third molar impacted surgery

La proteína C reactiva (CRP) por sus siglas en inglés) es una proteína de fase aguda que se utiliza para el seguimiento de enfermedades inflamatorias tales como artritis reumatoidea, lupus eritematoso o vasculitis y procesos infecciosos tales como sepsis y septicemia; así como también, para evaluar la eficacia de las drogas antiinflamatorias y antimicrobianas indicadas en el tratamiento de estas patologías. Igualmente se ha asociado a daño tisular en diversas especialidades quirúrgicas. El objetivo de este estudio fue relacionar los niveles plasmáticos de CRP con la infección y el edema posterior a la cirugía de los terceros molares. A tal efecto se evaluaron 60 pacientes, distribuidos en 3 grupos A, B y C bajo antibioticoterapia profiláctica con Clindamicina (A: dosis única de 600 mg, B: 300 mg c/6h por 5 días y C: Placebo) y terapia analgésica y antiinflamatoria (Ibuprofeno 400mg c/6h por 3 días). A quienes se tomaron muestras de sangre antes y a las 72 horas de la odontectomía de los terceros molares y fotografías digitales para calcular el área de inflamación. No se demostró la relación de los niveles de CRP con infección ya que ningún paciente presentó proceso infeccioso pero si se demostró la relación cualitativa (sensibilidad) de CRP y cuantitativa mediante correlación de Spearman (p<0,05) ya que mientras mayor fue el área de la inflamación, mayores fueron los niveles plasmáticos de CRP

The C reactive protein (CRP) is an unspecific acute phase reaction used for the follow-up of such inflammatory diseases such as rheumatoid arthritis, lupus, or vasculitis and such infectious processes like sepsis; as well as also, to evaluate the efficiency of the anti-inflammatory and antimicrobial drugs indicated in the treatment of this pathologies. Equally it has associated to tissue damage in diverse surgical specialties. The aim of this study was to evaluate the relation between CRP levels as indicator of postoperative infection and edema after third molar surgery. We evaluated 60 patients distributed in three groups A, B and C under antibiotic prophylaxis with Clindamycin (A: single dosis 600 mgs, B: 300 mgs each 6/h by 5 days and C: placebo) and analgesic and anti-inflammatory therapy with Ibuprofen 400 mg. each 6/h by 3 days. Who were taken blood samples to measure the CRP before and 72 hours after surgery and digital photographs to calculate the edema area. We did not demonstrated relation between CRP and infection because no one patient was infected in any group but we demonstrated (By Searman (p<0,05) the value of CRP as indicator of edema in the third molar surgery

Variaciones de la temperatura corporal de la interleuquina 6 y de la proteina C reactiva luego de la odontectomia de terceros molares / Changes in body temperature of the interleukin 6 and C-reactive protein after third molar odontectomy

Determinar las variaciones de la temperatura corporal, proteína C reactiva (PCR) y los niveles de Interleuquina 6 (IL-6) luego de la odontectomía de los terceros molares. Se seleccionaron 20 pacientes del Postgrado de Cirugía Bucal de la Facultad de Odontología de la Universidad Central de Venezuela, con indicación de extracción de los terceros molares retenidos y los cuales autorizaron por escrito su participación en el estudio. Los niveles de IL-6 fueron medidos por la prueba de ELISA, utilizando muestras de fluido crevicular gingival tomadas con puntas de papel estéril # 35, a las 0, 24, 48 horas y 7 días. Se realizó el registro de la temperatura corporal a las 0, 24, 48 horas y a los 7 días posteriores a la realización de la cirugía. Adicionalmente, se instruyó a los pacientes para la toma de la temperatura corporal cada 4 horas durante tres días consecutivos. Los niveles séricos de PCR se realizaron al tiempo 0 y a las 48 horas posteriores al acto quirúrgico. Se observó un aumento estadísticamente significativo en los niveles de IL-6, temperatura corporal y PCR luego de la odontectomía de los terceros molares. La elevación de la IL-6 se correlacionó en forma significativa con el incremento en la temperatura corporal y de la proteína C reactiva. La temperatura corporal, la IL-6 y la PCR aumentaron de manera directamente proporcional posterior al acto quirúrgico y en relación al trauma.

To determine variations in core body temperature, C-reactive protein (CRP) and interleukine-6 (IL-6) after surgical removal of third molars. Twenty patients who attended at the Oral Surgery Post grade in the Faculty of Dentistry, Universidad Central de Venezuela, for the extraction of the third molars. Informed consent was obtained from each patient. Samples of gingival crevicular fluid were collected with paper point # 35 at 0; 24 and 48 hours and at seventh day following to surgery, in order to measure IL-6 levels using ELISA test. The core body temperature was recorded at 0; 24; 48 hours and at 7th day after surgery. Additionally, the patients were instructed to register their temperature every 4 hours during three consecutive days. The CRP values were measured at time 0 and 48 hours later. Increase in IL-6, CRP and core body temperature values were observed after surgical extraction of third molars. The elevation of IL-6 was significantly correlated with the increase in CRP and body temperature. The core body temperature, IL-6 and CRP levels increased after surgical removal of third molars and were associated with the tissue damage.

Eficacia del tratamiento con amoxicilina en la prevención de complicaciones postoperatorias en pacientes sometidos a cirugía del tercer molar: un estudio doble ciego / Efficacy of Amoxicillin Treatment in Preventing Postoperative Complications in Patients Undergoing Third Molar Surgery: a Double Blind Study

El objetivo de esta investigación fue estudiar clínicamente la eficacia de la terapia con amoxicilina en terceros molares retenidos sobre las condiciones postoperatorias de edema, dolor, trismus e infección. Fueron seleccionados 14 pacientes de entre 15 y 30 años con la retención de los dientes 3.8 y 4.8 en la misma posición según las clasificaciones utilizadas actualmente. Se realizó inicialmente una cirugía y posteriormente la segunda; se estableció un grupo test con terapia antibiótica (amoxicilina 500mg c/8h por 7 días) y un grupo control que no utilizo antibióticos. El edema fue estudiado a través de la distancia de puntos faciales de referencia y la evaluación del trimus fue obtenida por medio de la distancia interincisal superior e inferior. El dolor fue estudiado mediante escala visual análoga. No existió diferencia estadísticamente significativa en relación al edema y al trismus en los periodos estudiados; existió diferencia estadísticamente significativa respecto al dolor durante los primeros dos días, siendo el grupo test que presentaba más dolor. A los 7 días ya no se apreció diferencias. Finalmente, la amoxicilina como terapia posterior a la exodoncia de terceros molares no se relaciona con las condiciones postoperatorias del paciente.

The aim of this study was to clinically evaluate the efficacy of antibiotics in retained third molar extractions, determining the need of antibiotics prophylaxis use in these procedures. Fourteen (14) patients, aged between 15 and 30 years, irrespective of sex, color or race were selected, for removal of retained third molars in symmetrical positions. The surgeries were divided into two groups: the control group in the first surgery and the second group undergoing prophylactic administration of 500 mg of amoxicillin 8 / 8 hours, for seven days after surgery. The evaluation of edema was established by the distance of reference points and assessment of facial trismus and was obtained by top and bottom interincisal distance. Measurements were performed before and after surgery, 24, 48 hours and for 7 days. Pain was evaluated subjectively by a visual analog scale. There was no statistically significant difference with respect to swelling and trismus after dental extractions with or without the use of antibiotics, and there was statistically significant difference in relation to pain in the postoperative periods of 24 and 48 hours, and increased pain reported by the test group. At day seven no differences were noted in perception of pain between the groups. Finally, the amoxicillin therapy subsequent to the third molar surgery is not related to the postoperatory conditions of the patient.